Our Research

We engineer molecular imaging tracers to understand biological processes, probe disease progression, and formulate treatment plans.

Image by National Cancer Institute

Monoclonal Antibodies (mAbs)

for Cancer Theranostics

Molecule

Framework Nucleic Acids (FNAs) for

kidney injury and nervous system management

Rational integration of tumor-specific mAbs and imaging/treatment radioisotopes may create theranostic pairs for early detection and timely intervention of cancer simultaneously.

 

Representative work:

1. Advanced Science 2019; 6(9): 1801237.

2. JNM 2020; doi: 10.2967/jnumed.120.246595.

3. EJNMMI 2018; 45(8): 1372-1381.

4. EJNMMI 2017; 44(8): 1296-1305.

5. Trends in Cancer 2018; 4(5): 359-373.

Oligonucleotides are devised into DNA frameworks as biocompatible/biodegradable molecular probes for imaging and treating renal injury and cerebral dysfunction.

Representative work:

1. Nature Biomedical Engineering 2018; 2(11): 865-877.

2. Acc. Chem. Res. 2020. doi: 10.1021/acs.accounts.0c00323.

3. Advanced Science 2020; 7(12): 2000420.

4. Nano Letters 2019; 19(10): 7334-7341.

5. Nano Research 2019; 12(3): 637-642.